I. Product Overview
Closed-loop Transcranial Temporal Interference Deep Electrical Stimulator Platform is an advanced non-invasive brain stimulation system oriented to neuroscience research and neuromodulation applications. Based on the principle of Temporal Interference Stimulation (TI), this platform generates a low-frequency modulated electric field deep in brain tissue through multi-channel high-frequency carrier currents. It enables precise and controllable modulation of deep brain regions without significantly stimulating the superficial cortex. The system integrates real-time neural signal acquisition, adaptive adjustment of stimulation parameters and intelligent algorithm analysis modules to build a complete closed-loop neuromodulation platform, providing highly reliable solutions for basic research, clinical research and neuroengineering applications.
II. Functional Features
1. Temporal Interference Deep Brain Stimulation: Multiple high-frequency electric currents form a low-frequency envelope in the target area to achieve selective stimulation of deep brain regions;
2. Closed-loop Regulation Mechanism: Collect electroencephalogram/neural electrical signals in real time, and dynamically adjust stimulation parameters based on neural feedback;
3. Multi-channel Independent Control: Support independent configuration of amplitude, phase and frequency for multiple stimulation channels;
4. High-precision Timing Synchronization: Highly synchronous stimulation and acquisition system to ensure consistency of data and regulation;
5. Flexible Protocol Editing: Support customization of multiple stimulation modes and experimental procedures;
6. High-safety Design: Adopt multiple electrical isolation and current limiting protection to ensure the safety of subjects.
III. Application Scenarios and Fields
1. Fundamental Neuroscience Research: Functional regulation of deep brain regions and research on neural network dynamics;
2. Neurological Disease Research: Mechanistic studies on depression, Parkinson's disease, epilepsy, chronic pain and other related disorders;
3. Cognitive and Behavioral Science: Research on the regulation of memory, learning, attention and decision-making;
4. Brain-Computer Interface Research: Combined application with electroencephalography or other neural signal systems;
5. Neuromodulation Technology Verification: Evaluation and comparative experiments of novel non-invasive stimulation methods.
IV. Technical Advantages
1. Non-invasive deep modulation capability: Significantly improves the selectivity of deep stimulation compared with traditional transcranial electrical stimulation;
2. Closed-loop intelligent control: Enables individualized and state-dependent stimulation based on real-time neural feedback;
3. High spatial and temporal resolution: Precisely controls stimulation focus and stimulation timing sequence;
4. Excellent system scalability: Can be seamlessly integrated with various neural signal acquisition and analysis systems;
5. Stable and reliable platform architecture: Suitable for long-term experiments and multi-center research deployment.
V. Typical Models and Application Cases
Model | Features | Application Cases | Applicable Objects |
Basic Research-oriented Closed-loop Transcranial Temporal Interference Deep Brain Stimulation Platform | - Support dual-channel or multi-channel high-frequency carrier output - Basic closed-loop control (triggering or adjustment based on EEG/LFP features) - Support for offline and semi-real-time stimulation strategies - Highlight adjustable parameter range and experimental flexibility
| · Study on the regulation of thalamocortical pathways
· Experimental exploration of basal ganglia functions
· Research on the coupling mechanism of deep neural oscillations | Targeting universities and research institutes, it is applied to explore the mechanism of temporal interference stimulation in deep brain regions and the regulatory rules of neural circuits, with emphasis on stimulation controllability and experimental flexibility. |
Closed-loop Neurofeedback Regulation Research Platform (Advanced Research Type) | · Multi-channel high-frequency stimulation + high-density EEG real-time acquisition
· Supports extraction of multiple neural features (power spectrum, phase synchronization, entropy, etc.)
· Stimulation parameters can be automatically adjusted according to neural states
· Supports individualized stimulation strategies
| · Closed-loop Intervention Experiment on Depressive-like Neural State
· Study on the Suppression of Epileptic Precursor State
· Central Regulation Experiment of Chronic Pain | Used for the research of neuromodulation mechanisms and disease model research, with an emphasis on real-time closed-loop, adaptive regulation and individual difference modeling |
Multimodal Joint Research Platform (Extended / Comprehensive) | · Synchronization of temporal interference stimulation with EEG, fNIRS and behavioral systems · Multi-timescale data alignment · Support for experimental-level synchronous triggering and joint analysis · Design for complex task paradigms
| · Study on Deep Brain Region Modulation in Cognitive Tasks
· Multimodal Research on Emotional Processing
· Functional Connectivity Analysis of Neural Networks
| Used for the research of complex nervous systems, it supports coordinated operation with various neuroimaging, behavioral and electrophysiological systems. |
Research Platform for Brain-Computer Interface and Neural Engineering | - Tightly coupled stimulation and decoding module - Supports stimulation driven by external control signals or algorithms - Enables the construction of a complete closed loop of "perception-decision-stimulation" - Oriented to joint verification of algorithms and systems | · Research on Deep Brain Stimulation Assisted Brain-Computer Interface Control · Experiment on Neural Plasticity Induction · Research on Human-Machine Collaborative Regulation Model
| For the field of brain-computer interface and neural engineering, it is used to study the stimulus-perception-behavior feedback closed-loop system. |
Methodological Verification and Comparative Research Platform | · Supports switching of multiple stimulation modes · High-consistency parameter control · Oriented to methodological evaluation and repetitive experiments · Suitable for standardized research
| · Comparative Experiment of Temporal Domain Interference and Traditional Transcranial Stimulation
· Research on Optimization of Stimulation Focus and Modulation Frequency
· Safety and Tolerability Evaluation Experiment
| Used for research on novel neurostimulation methodologies, conducting systematic comparisons with conventional technologies such as tDCS, tACS and tTIS. |
Equipment Appearance Drawing
